Chemical structure--acute toxicity relation of m-substituted derivatives N,N-dimethyl-4-aminoazobenzene with hepatocarcinogen effects.


The mol LD50 values were correlated with Hammett sigma constants in terms of the Hansen empiric equation 7 for meta substituted derivatives of N,N-dimethyl-4-aminoazobenzene. Good agreement and the line slope of the correlation was achieved. Relation acute toxicity--carcinogenity was discussed in the end.


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